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101.
Yanovskii L. S. Lempert D. B. Raznoschikov V. V. Aver’kov I. S. 《Russian Journal of Applied Chemistry》2019,92(3):367-388
Russian Journal of Applied Chemistry - The possibility of replacing the currently widely used ammonium perchlorate as an oxidizing agent (dispersant) in the composition of solid boron-containing... 相似文献
102.
Salikhov Sh. M. Latypova L. R. Mustafin A. G. Ayupov D. S. Vasilova L. Ya. Zorin V. V. Abdrakhmanov I. B. 《Russian Journal of Organic Chemistry》2019,55(10):1539-1546
Russian Journal of Organic Chemistry - The nitration, oxidative halogenation, and radical bromination and chlorination of 2-ethyl-2-methyl-2,3-dihydro-1H-indole afforded the corresponding nitro,... 相似文献
103.
Dr. Safaa M. Kishk Dr. Kirsty J. McLean Dr. Sakshi Sood Darren Smith Jack W.D. Evans Prof. Mohamed A. Helal Prof. Mohamed S. Gomaa Prof. Ismail Salama Prof. Samia M. Mostafa Dr. Luiz Pedro S. de Carvalho Colin W. Levy Prof. Andrew W. Munro Dr. Claire Simons 《ChemistryOpen》2019,8(7):995-1011
The emergence of untreatable drug-resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new efficient treatments is urgently needed. Mycobacterium tuberculosis cytochrome P450 CYP121A1 is a promising drug target for the treatment of tuberculosis owing to its essential role in mycobacterial growth. Using a rational approach, which includes molecular modelling studies, three series of azole pyrazole derivatives were designed through two synthetic pathways. The synthesized compounds were biologically evaluated for their inhibitory activity towards M. tuberculosis and their protein binding affinity (KD). Series 3 biarylpyrazole imidazole derivatives were the most effective with the isobutyl ( 10 f ) and tert-butyl ( 10 g ) compounds displaying optimal activity (MIC 1.562 μg/mL, KD 0.22 μM ( 10 f ) and 4.81 μM ( 10 g )). The spectroscopic data showed that all the synthesised compounds produced a type II red shift of the heme Soret band indicating either direct binding to heme iron or (where less extensive Soret shifts are observed) putative indirect binding via an interstitial water molecule. Evaluation of biological and physicochemical properties identified the following as requirements for activity: LogP >4, H-bond acceptors/H-bond donors 4/0, number of rotatable bonds 5–6, molecular volume >340 Å3, topological polar surface area <40 Å2. 相似文献
104.
Sulyanova E. A. Bolotina N. B. Kalukanov A. I. Sorokin N. I. Karimov D. N. Verin I. A. Sobolev B. P. 《Crystallography Reports》2019,64(1):41-50
Crystallography Reports - The defect structure of as-grown SrF2 and nonstoichiometric phases Sr1 – xLaxF2 + x (x = 0.11, 0.20, 0.32, 0.37, 0.47) single... 相似文献
105.
Mikhailovskii A. G. Peretyagin D. A. Dmitriev M. V. 《Russian Journal of Organic Chemistry》2019,55(5):633-639
Russian Journal of Organic Chemistry - The reaction of 6,6-dialkyl-5,6-dihydrobenzo[f]pyrrolo[2,1-a]isoquinoline-8,9-diones with hydrazine is used to prepare enaminoketohydrazides of the... 相似文献
106.
Prokhorov I. A. Voloshin A. E. Romanov D. A. Bolshakov A. P. Ralchenko V. G. 《Crystallography Reports》2019,64(3):392-397
Crystallography Reports - The real structures of epitaxial CVD films of germanium and diamond have been comparatively analyzed. The influence of the specific features of elastic-stress distribution... 相似文献
107.
Stolpovskaya N. V. Kruzhilin A. A. Zorina A. V. Shikhaliev Kh. S. Ledeneva I. V. Kosheleva E. A. Vandyshev D. Yu. 《Russian Journal of Organic Chemistry》2019,55(9):1322-1328
Russian Journal of Organic Chemistry - A procedure has been proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by... 相似文献
108.
Gabrielle A. Leith Allison M. Rice Brandon J. Yarbrough Anna A. Berseneva Richard T. Ly Charles N. Buck III Dr. Denis Chusov Amy J. Brandt Prof. Dr. Donna A. Chen Benjamin W. Lamm Prof. Dr. Morgan Stefik Kenneth S. Stephenson Dr. Mark D. Smith Prof. Dr. Aaron K. Vannucci Dr. Perry J. Pellechia Prof. Dr. Sophya Garashchuk Prof. Dr. Natalia B. Shustova 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(15):6056-6062
The effect of donor (D)–acceptor (A) alignment on the materials electronic structure was probed for the first time using novel purely organic porous crystalline materials with covalently bound two- and three-dimensional acceptors. The first studies towards estimation of charge transfer rates as a function of acceptor stacking are in line with the experimentally observed drastic, eight-fold conductivity enhancement. The first evaluation of redox behavior of buckyball- or tetracyanoquinodimethane-integrated crystalline was conducted. In parallel with tailoring the D-A alignment responsible for “static” changes in materials properties, an external stimulus was applied for “dynamic” control of the electronic profiles. Overall, the presented D–A strategic design, with stimuli-controlled electronic behavior, redox activity, and modularity could be used as a blueprint for the development of electroactive and conductive multidimensional and multifunctional crystalline porous materials. 相似文献
109.
Bitar D. Ture Savadkoohi A. Lamarque C.-H. Gourdon E. Collet M. 《Nonlinear dynamics》2020,99(2):1433-1450
Nonlinear Dynamics - The present research work aims to design a passive vibration control based on nonlinear energy pumping. An extended asymptotic approach is introduced based on the invariant... 相似文献
110.
Mathematical Notes - A logistic delay equation with diffusion, which is important in applications, is studied. It is assumed that all of its coefficients, as well as the coefficients in the... 相似文献